PKC differentially translocates during spaced and massed training in Aplysia.

@article{Farah2009PKCDT,
  title={PKC differentially translocates during spaced and massed training in Aplysia.},
  author={Carole A. Farah and Daniel B. Weatherill and Tyler William Dunn and Wayne S. Sossin},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 33},
  pages={10281-6}
}
Learning is highly regulated by the pattern of training. In Aplysia, an important organism for the development of cellular and molecular models of learning, spaced versus massed application of the same stimulus leads to different forms of memory. A critical molecular step underlying memory is the serotonin (5HT)-mediated activation of the novel PKC Apl II. Here, we demonstrate that activation of PKC Apl II is highly sensitive to the pattern of 5HT application. Spaced applications downregulate… CONTINUE READING

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