PKC-dependent phosphorylation of Munc18a at Ser313 in activated RBL-2H3 cells

@article{Adhikari2017PKCdependentPO,
  title={PKC-dependent phosphorylation of Munc18a at Ser313 in activated RBL-2H3 cells},
  author={Pratikshya Adhikari and Hao Xu},
  journal={Inflammation Research},
  year={2017},
  volume={67},
  pages={1-3}
}
Protein Kinase C (PKC) regulates the release of pro-inflammatory compounds from IgE/antigen-activated mast cells by unknown mechanisms. In this study, we show for the first time that PKC inhibitor Ro-03-0432, which inhibits RBL-2H3 exocytosis/degranulation in a concentration-dependent fashion, prevents the phosphorylation of membrane fusion factor Munc18a at Ser 313. Our study provides fresh evidence that PKC-dependent protein phosphorylation may contribute to the intricate regulation of mast… 

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