PKC delta is essential for Dishevelled function in a noncanonical Wnt pathway that regulates Xenopus convergent extension movements.

@article{Kinoshita2003PKCDI,
  title={PKC delta is essential for Dishevelled function in a noncanonical Wnt pathway that regulates Xenopus convergent extension movements.},
  author={Noriyuki Kinoshita and Hidekazu Iioka and Akira Miyakoshi and Naoto Ueno},
  journal={Genes & development},
  year={2003},
  volume={17 13},
  pages={1663-76}
}
Protein kinase C (PKC) has been implicated in the Wnt signaling pathway; however, its molecular role is poorly understood. We identified novel genes encoding delta-type PKC in the Xenopus EST databases. Loss of PKC delta function revealed that it was essential for convergent extension during gastrulation. We then examined the relationship between PKC delta and the Wnt pathway. PKC delta was translocated to the plasma membrane in response to Frizzled signaling. In addition, loss of PKC delta… CONTINUE READING
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