PKC-delta and -epsilon regulate NF-kappaB activation induced by cholecystokinin and TNF-alpha in pancreatic acinar cells.

@article{Satoh2004PKCdeltaA,
  title={PKC-delta and -epsilon regulate NF-kappaB activation induced by cholecystokinin and TNF-alpha in pancreatic acinar cells.},
  author={Akihiko Satoh and Anna S. Gukovskaya and Jos{\'e} Mar{\'i}a Nieto and J. H. Cheng and I. Ya. Gukovsky and Joseph R. Reeve and Tooru Shimosegawa and Stephen J Pandol},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2004},
  volume={287 3},
  pages={G582-91}
}
Although NF-kappaB plays an important role in pancreatitis, mechanisms underlying its activation remain unclear. We investigated the signaling pathways mediating NF-kappaB activation in pancreatic acinar cells induced by high-dose cholecystokinin-8 (CCK-8), which causes pancreatitis in rodent models, and TNF-alpha, which contributes to inflammatory responses of pancreatitis, especially the role of PKC isoforms. We determined subcellular distribution and kinase activities of PKC isoforms and NF… CONTINUE READING
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