PKC-beta1 mediates glucose-induced Akt activation and TGF-beta1 upregulation in mesangial cells.

@article{Wu2009PKCbeta1MG,
  title={PKC-beta1 mediates glucose-induced Akt activation and TGF-beta1 upregulation in mesangial cells.},
  author={Dongcheng Wu and Fangfang Peng and Baifang Zhang and Alistair J. Ingram and Darren J. Kelly and Richard E Gilbert and Bo Gao and Joan C Krepinsky},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2009},
  volume={20 3},
  pages={554-66}
}
Accumulation of glomerular matrix is a hallmark of diabetic nephropathy. The serine/threonine kinase Akt mediates glucose-induced upregulation of collagen I in mesangial cells through transactivation of the EGF receptor (EGFR). In addition, in renal tubular cells, glucose-induced secretion of TGF-beta requires phosphoinositide-3-OH kinase, suggesting a possible role for Akt in the modulation of TGF-beta expression, but the mechanisms of Akt activation and its involvement in TGF-beta regulation… CONTINUE READING

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