PKC and PLA2: probing the complexities of the calcium network.

  title={PKC and PLA2: probing the complexities of the calcium network.},
  author={Damian B. van Rossum and Randen L. Patterson},
  journal={Cell calcium},
  volume={45 6},
Lipid signaling and phosphorylation cascades are fundamental to calcium signaling networks. In this review, we will discuss the recent laboratory findings for the phospholipase A(2) (PLA(2))/protein kinase C (PKC) pathway within cellular calcium networks. The complexity and connectivity of these ubiquitous cellular signals make interpretation of experimental results extremely challenging. We present here computational methods which have been developed to conquer such complex data, and how they… CONTINUE READING

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