PKC activation sets an upper limit to the functional plasticity of GABAergic transmission induced by endogenous neurosteroids.

@article{Vergnano2007PKCAS,
  title={PKC activation sets an upper limit to the functional plasticity of GABAergic transmission induced by endogenous neurosteroids.},
  author={Angela Maria Vergnano and R{\'e}my Schlichter and Pierrick Poisbeau},
  journal={The European journal of neuroscience},
  year={2007},
  volume={26 5},
  pages={1173-82}
}
The activity of GABAergic inhibitory interneurones located in lamina II of the spinal cord is of fundamental importance for the processing of peripheral nociceptive messages. We have recently shown that 3alpha-hydroxy ring A-reduced pregnane neurosteroids [3alpha5alpha-neurosteroids (3alpha5alphaNS)], potent allosteric modulators of GABA(A) receptors (GABA(A)Rs), are synthesized in the spinal cord and limit thermal hyperalgesia during inflammatory pain. Because changes in the expression of… CONTINUE READING

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Journal Compilation a Federation of European Neuroscience Societies and Blackwell Publishing Ltd

  • A. M. Vergnano
  • 2007

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