PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90

@inproceedings{Lafayette2010PKCSR,
  title={PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90},
  author={Shantelle L. Lafayette and Cathy Collins and Aimee K. Zaas and Wiley A. Schell and Marisol Betancourt-Quiroz and A A Leslie Gunatilaka and John R Perfect and Leah E Cowen},
  booktitle={PLoS pathogens},
  year={2010}
}
Fungal pathogens exploit diverse mechanisms to survive exposure to antifungal drugs. This poses concern given the limited number of clinically useful antifungals and the growing population of immunocompromised individuals vulnerable to life-threatening fungal infection. To identify molecules that abrogate resistance to the most widely deployed class of antifungals, the azoles, we conducted a screen of 1,280 pharmacologically active compounds. Three out of seven hits that abolished azole… CONTINUE READING
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