PKC-θ is a negative regulator of TRAIL-induced and FADD-mediated apoptotic spectrin aggregation.

@article{Michalczyk2015PKCIA,
  title={PKC-θ is a negative regulator of TRAIL-induced and FADD-mediated apoptotic spectrin aggregation.},
  author={Izabela Michalczyk and Monika Toporkiewicz and Patrycja M. Dubielecka and Anna D Chorzalska and Aleksander F. Sikorski},
  journal={Folia histochemica et cytobiologica},
  year={2015},
  volume={54 1},
  pages={
          1-13
        }
}
INTRODUCTION During studies on chemotherapy-induced apoptosis in lymphoid cells, we noted that aggregation of spectrin occurred early in apoptosis, i.e. before activation of initiator caspase(s) and prior to exposure of phosphatidylserine (PS). We also found that protein kinase C theta (PKC-θ) co-localized with spectrin in these aggregates. Our previously published studies indicated that in formation of early apoptotic spectrin aggregates, either PKC-θ or other apoptosis-related proteins are… CONTINUE READING

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