PKC-ε is upstream and PKC-α is downstream of mitoKATP channels in the signal transduction pathway of ischemic preconditioning of human myocardium

@article{Hassouna2004PKCIU,
  title={PKC-$\epsilon$ is upstream and PKC-$\alpha$ is downstream of mitoKATP channels in the signal transduction pathway of ischemic preconditioning of human myocardium},
  author={Ashraf Hamed Hassouna and Bashir Mnene Matata and Manuel Gali{\~n}anes},
  journal={American Journal of Physiology-cell Physiology},
  year={2004},
  volume={287}
}
Protein kinase C (PKC) is involved in the process of ischemic preconditioning (IPC), although the precise mechanism is still a subject of debate. Using specific PKC inhibitors, we investigated whic... 
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85 Citations

Diazoxide acts more as a PKC‐ɛ activator, and indirectly activates the mitochondrial KATP channel conferring cardioprotection against hypoxic injury

This work aimed to clarify the role of PKC isoforms and the relationship between the PKCISO forms and the mitoKATP channel in diazoxide‐induced cardioprotection.

Mechanisms by which K(ATP) channel openers produce acute and delayed cardioprotection.

Mitochondrial ATP-sensitive potassium channels and mitochondrial protein kinase C: sometimes it's good to have a close neighbor.

  • G. Grover
  • Biology
    American journal of physiology. Heart and circulatory physiology
  • 2006
The fine study by Jiang et al. is an important milestone in the ongoing studies on the role of the mitochondrial ATP-sensitive K+ (mitoKATP) channels in myocardial ischemia.

Signaling pathways involved in postconditioning-induced cardioprotection of human myocardium, in vitro

In conclusion, PKC activation, opening of mitoKATP channels and p38 MAPK activation in early reoxygenation induced the postconditioning of human myocardium, in vitro.

Signaling Mechanisms in Ischemic Preconditioning: Interaction of PKCε and MitoKATP in the Inner Membrane of Mitochondria

IPC is a process in which brief periods of ischemia improves the ability of the heart to tolerate subsequent prolonged ischemic periods, and the opening of a mitochondrial channel is believed to be critical for the induction of IPC.

MitoKATP channel activation suppresses gap junction permeability in the ischemic myocardium by an ERK-dependent mechanism.

H2S preconditioning-induced PKC activation regulates intracellular calcium handling in rat cardiomyocytes.

Functional Analysis of Regulatory Phosphorylation Events in Cardiac KATP Channel Subunits in Ischaemia

It was found that PKC activator, Phorbol 12-Myristate 13-Acetate (PMA), inhibited pinacidil-activated Kir 6.1/SUR2A and Kir6.1-containing KATP channels using the whole cell patch clamp technique and the inhibitory effect of PKC was abolished in this mutant.

The Interaction of Isoflurane and Protein Kinase C-Activators on Sarcolemmal KATP Channels

It is found that exposure of isolated guinea pig cardiomyocytes to 1 mM of isoflurane after phorbol ester stimulation of PKC facilitates the induction of larger (P ≤ 0.05) sarcolemmal KATP channel currents (IKATP) during cell dialysis with 0.5, compared to 1.0, mM of ATP in the pipette.

Phospholipase C as a potential target for cardioprotection during oxidative stress.

The historical and current information on PLC-mediated signal transduction mechanisms in I/R are reviewed, as well as outlining future directions that should be addressed to extend knowledge of ischemic heart disease and improve its therapy.
...

References

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We examined whether the mitochondrial ATP-sensitive K channel (KATP) is an effector downstream of protein kinase C-e (PKC-e) in the mechanism of preconditioning (PC) in isolated rabbit hearts. PC w...

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...