PKC ε activation prevents synaptic loss, Aβ elevation, and cognitive deficits in Alzheimer's disease transgenic mice.

@article{Hongpaisan2011PKCA,
  title={PKC ε activation prevents synaptic loss, Aβ elevation, and cognitive deficits in Alzheimer's disease transgenic mice.},
  author={Jarin Hongpaisan and Miao-Kun Sun and Daniel L. Alkon},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 2},
  pages={630-43}
}
Among the pathologic hallmarks of Alzheimer's disease (AD) neurodegeneration, only synaptic loss in the brains of AD patients closely correlates with the degree of dementia in vivo. Here, we describe a molecular basis for this AD loss of synapses: pathological reduction of synaptogenic PKC isozymes and their downstream synaptogenic substrates, such as brain-derived neurotrophic factor. This reduction, particularly of PKC α and ε, occurs in association with elevation of soluble β amyloid protein… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 52 extracted citations

New Drugs from Marine Organisms in Alzheimer’s Disease

Marine drugs • 2015
View 5 Excerpts
Highly Influenced

The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer's disease.

Proceedings of the National Academy of Sciences of the United States of America • 2018

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease.

Proceedings of the National Academy of Sciences of the United States of America • 2006
View 5 Excerpts
Highly Influenced

triggered by local contact with astrocytes

J Hongpaisan, DL Alkon
2007
View 7 Excerpts
Highly Influenced

PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice.

Proceedings of the National Academy of Sciences of the United States of America • 2006
View 5 Excerpts
Highly Influenced

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2002
View 4 Excerpts
Highly Influenced

Postischemic PKC activation rescues retrograde and anterograde long-term memory.

Proceedings of the National Academy of Sciences of the United States of America • 2009
View 1 Excerpt

Similar Papers

Loading similar papers…