PKC-β activation inhibits IL-18-binding protein causing endothelial dysfunction and diabetic atherosclerosis.

@article{Durps2015PKCAI,
  title={PKC-β activation inhibits IL-18-binding protein causing endothelial dysfunction and diabetic atherosclerosis.},
  author={Marie-Claude Durp{\`e}s and Catherine L Morin and Judith Paquin-Veillet and Rapha{\"e}l B{\'e}land and Martin Par{\'e} and M C Guimond and Mark D. Rekhter and George L King and Pedro Geraldes},
  journal={Cardiovascular research},
  year={2015},
  volume={106 2},
  pages={303-13}
}
AIMS Clinical observations showed a correlation between accelerated atherosclerosis in diabetes and high plasmatic level of IL-18, a pro-inflammatory cytokine. IL-18 enhances the production of inflammatory cytokines and cellular adhesion molecules contributing to atherosclerotic plaque formation and instability. Previous studies indicated that protein kinase C (PKC)-β inhibition prevented macrophage-induced cytokine expression involved in diabetic (DM) atherosclerotic plaque development… CONTINUE READING
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