PKCθ is a Key Regulator of T-cell Behavior and a Drug Target for T cell-mediated Diseases

@inproceedings{Isakov2012PKCIA,
  title={PKCθ is a Key Regulator of T-cell Behavior and a Drug Target for T cell-mediated Diseases},
  author={Noah Isakov},
  year={2012}
}
The protein kinase C-theta (PKCθ) isoform is a member of the calcium-independent novel PKC subfamily of serine/threonine kinases. It is an essential regulatory enzyme in mature T lymphocytes, where it plays a key role in coupling the activated TCR and the CD28 costimulatory receptor to their downstream signaling pathways. TCR/ CD28 engagement induces the translocation of PKCθ to the center of the immunological synapse where it undergoes posttranslational modifications and becomes fully active… CONTINUE READING

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