PKCθ Regulates T-Cell Leukemia-Initiating Activity via Reactive Oxygen Species

@inproceedings{Giambra2012PKCRT,
  title={PKCθ Regulates T-Cell Leukemia-Initiating Activity via Reactive Oxygen Species},
  author={Vincenzo Giambra and Christopher R. Jenkins and Hongfang Wang and Sonya H L Lam and Olena O. Shevchuk and Oksana Nemirovsky and Carol Wai and Sam Gusscott and Mark Y Chiang and Jon C Aster and Richard Keith Humphries and Connie J. Eaves and Andrew P. Weng},
  booktitle={Nature Medicine},
  year={2012}
}
Reactive oxygen species (ROS), a byproduct of cellular metabolism, damage intracellular macromolecules and, when present in excess, can promote normal hematopoietic stem cell differentiation and exhaustion. However, mechanisms that regulate the amount of ROS in leukemia-initiating cells (LICs) and the biological role of ROS in these cells are largely unknown. We show here that the ROSlow subset of CD44+ cells in T cell acute lymphoblastic leukemia (T-ALL), a malignancy of immature T cell… CONTINUE READING