PKCε-dependent potentiation of TTX-resistant Nav1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neurons

@article{Cang2009PKCdependentPO,
  title={PKCε-dependent potentiation of TTX-resistant Nav1.8 current by neurokinin-1 receptor activation in rat dorsal root ganglion neurons},
  author={Chun-Lei Cang and Hua Zhang and Yu-qiu Zhang and Zhi-qi Zhao},
  journal={Molecular Pain},
  year={2009},
  volume={5},
  pages={33 - 33}
}
BACKGROUND Substance P (SP), which mainly exists in a subtype of small-diameter dorsal root ganglion (DRG) neurons, is an important signal molecule in pain processing in the spinal cord. Our previous results have proved the expression of SP receptor neurokinin-1 (NK-1) on DRG neurons and its interaction with transient receptor potential vanilloid 1 (TRPV1) receptor. RESULTS In this study we investigated the effect of NK-1 receptor agonist on Na(v)1.8, a tetrodotoxin (TTX)-resistant sodium… CONTINUE READING