PKCδ knockout mice are protected from para-methoxymethamphetamine-induced mitochondrial stress and associated neurotoxicity in the striatum of mice.

@article{Shin2016PKCKM,
  title={PKCδ knockout mice are protected from para-methoxymethamphetamine-induced mitochondrial stress and associated neurotoxicity in the striatum of mice.},
  author={Eun-joo Shin and Duy-Khanh Dang and H Tran and Yunsung Nam and Ji Hoon Jeong and Young Hun Lee and Kyung Tae Park and Yong Sup Lee and C G Jang and Jau-Shyong Hong and Toshitaka Nabeshima and Hyoung Chun Kim},
  journal={Neurochemistry international},
  year={2016},
  volume={100},
  pages={146-158}
}
Para-methoxymethamphetamine (PMMA) is a para-ring-substituted amphetamine derivative sold worldwide as an illegal psychotropic drug. Although PMMA use has been reported to lead to severe intoxication and even death, little is known about the mechanism(s) by which PMMA exerts its neurotoxic effects. Here we found that PMMA treatment resulted in phosphorylation of protein kinase Cδ (PKCδ) and subsequent mitochondrial translocation of cleaved PKCδ. PMMA-induced oxidative stress was more pronounced… CONTINUE READING