PKCβ regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1


The B cell antigen receptor (BCR)–mediated activation of I B kinase (IKK) and nuclear factor– B require protein kinase C (PKC) ; however, the mechanism by which PKC regulates IKK is unclear. Here, we demonstrate that another protein kinase, TGF -activated kinase (TAK)1, is essential for IKK activation in response to BCR stimulation. TAK1 interacts with the… (More)


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