PKCβ promotes vascular inflammation and acceleration of atherosclerosis in diabetic ApoE null mice.

@article{Kong2013PKCPV,
  title={PKCβ promotes vascular inflammation and acceleration of atherosclerosis in diabetic ApoE null mice.},
  author={Linghua Kong and Xiaoping Shen and Lili Lin and Michael Leitges and Rosa Rosario and Yu Shan Zou and Shi Fang Yan},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2013},
  volume={33 8},
  pages={
          1779-87
        }
}
OBJECTIVE Subjects with diabetes mellitus are at high risk for developing atherosclerosis through a variety of mechanisms. Because the metabolism of glucose results in production of activators of protein kinase C (PKC)β, it was logical to investigate the role of PKCβ in modulation of atherosclerosis in diabetes mellitus. APPROACH AND RESULTS ApoE(-/-) and PKCβ(-/-)/ApoE(-/-) mice were rendered diabetic with streptozotocin. Quantification of atherosclerosis, gene expression profiling, or… CONTINUE READING
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