PKA phosphorylations on tau: developmental studies in the mouse.

@article{Andorfer2000PKAPO,
  title={PKA phosphorylations on tau: developmental studies in the mouse.},
  author={Cathy Andorfer and Peter Davies},
  journal={Developmental neuroscience},
  year={2000},
  volume={22 4},
  pages={303-9}
}
PKA phosphorylations of tau may be an early event in the development of neurofibrillary pathology in Alzheimer's disease. Serines 214 and 409 of tau are highly phosphorylated in PHF-tau, but are not phosphorylated to any significant extent in normal adult human brain; both of these sites are phosphorylated in human fetal tissue. To further study this phenomenon, a developmental characterization of these phosphorylation sites relative to PKA, cAMP-dependent response binding element (CREB) and… CONTINUE READING
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