PKA phosphorylation of cardiac ryanodine receptor modulates SR luminal Ca2+ sensitivity.

@article{Ullrich2012PKAPO,
  title={PKA phosphorylation of cardiac ryanodine receptor modulates SR luminal Ca2+ sensitivity.},
  author={Nina D. Ullrich and H{\'e}ctor H. Valdivia and E. Niggli},
  journal={Journal of molecular and cellular cardiology},
  year={2012},
  volume={53 1},
  pages={33-42}
}
During physical exercise and stress, the sympathetic system stimulates cardiac contractility via β-adrenergic receptor activation, resulting in protein kinase A (PKA)-mediated phosphorylation of the cardiac ryanodine receptor, RyR2, at Ser2808. Hyperphosphorylation of RyR2-S2808 has been proposed as a mechanism contributing to arrhythmogenesis and heart failure. However, the role of RyR2 phosphorylation during β-adrenergic stimulation remains controversial. We examined the contribution of RyR2… CONTINUE READING
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