PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells.

@article{Pasqualucci2006PKAmediatedPR,
  title={PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells.},
  author={Laura Pasqualucci and Yasuyuki Kitaura and Hua Gu and Riccardo Dalla-Favera},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 2},
  pages={395-400}
}
During humoral immune responses, two distinct genetic modification events diversify the Ig genes in germinal center (GC) B cells: somatic hypermutation and class switch recombination (CSR). Both processes require the activity of activation-induced cytidine deaminase (AID), an enzyme expressed specifically in GC B cells. However, the mechanisms that regulate AID activity are largely unknown. Here we report that protein kinase A (PKA) phosphorylates AID and regulates its activity in GC B cells… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
86 Citations
1 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 86 extracted citations

References

Publications referenced by this paper.

www.pnas.org cgi doi 10.1073 pnas.0509969103 Pasqualucci et al. WT DM S38A T27A ph os ph at e la be lin g

  • L. Zhang, C. J. Duan, +4 authors D. M. Simeone
  • Mol. Cell. Biol
  • 2004
1 Excerpt

Similar Papers

Loading similar papers…