PKA-dependent phosphorylation of ribosomal protein S6 does not correlate with translation efficiency in striatonigral and striatopallidal medium-sized spiny neurons.

Abstract

Ribosomal protein S6 (rpS6), a component of the 40S ribosomal subunit, is phosphorylated on several residues in response to numerous stimuli. Although commonly used as a marker for neuronal activity, its upstream mechanisms of regulation are poorly studied and its role in protein synthesis remains largely debated. Here, we demonstrate that the… (More)
DOI: 10.1523/JNEUROSCI.3288-14.2015

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@article{Biever2015PKAdependentPO, title={PKA-dependent phosphorylation of ribosomal protein S6 does not correlate with translation efficiency in striatonigral and striatopallidal medium-sized spiny neurons.}, author={Anne Biever and Emma Puighermanal and Akinori Nishi and Alexandre David and Claire Panciatici and Sophie Longueville and Dimitris P. Xirodimas and Giuseppe Gangarossa and Oded Meyuhas and Denis Herv{\'e} and Jean-Antoine Girault and Emmanuel Valjent}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={2015}, volume={35 10}, pages={4113-30} }