PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling.

@article{Yang2014PKACS,
  title={PKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling.},
  author={Jason H Yang and Renata K. Polanowska-Grabowska and Jeffrey S Smith and Charles Shields and Jeffrey J. Saucerman},
  journal={Journal of molecular and cellular cardiology},
  year={2014},
  volume={66},
  pages={
          83-93
        }
}
β-Adrenergic signaling is spatiotemporally heterogeneous in the cardiac myocyte, conferring exquisite control to sympathetic stimulation. Such heterogeneity drives the formation of protein kinase A (PKA) signaling microdomains, which regulate Ca(2+) handling and contractility. Here, we test the hypothesis that the nucleus independently comprises a PKA signaling microdomain regulating myocyte hypertrophy. Spatially-targeted FRET reporters for PKA activity identified slower PKA activation and… CONTINUE READING
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