PKA and MAPK phosphorylation of Prf1 allows promoter discrimination in Ustilago maydis.

@article{Kaffarnik2003PKAAM,
  title={PKA and MAPK phosphorylation of Prf1 allows promoter discrimination in Ustilago maydis.},
  author={Florian Kaffarnik and Philip Mueller and Marc Leibundgut and Regine Kahmann and Michael Feldbr{\"u}gge},
  journal={The EMBO journal},
  year={2003},
  volume={22 21},
  pages={
          5817-26
        }
}
Mating in Ustilago maydis requires cross-talk between cAMP and mitogen-activated protein kinase (MAPK) signalling. During this process, pheromone response factor 1 (Prf1) activates transcription of a and b mating type genes by binding to pheromone response elements (PREs) located in regulatory regions of these genes. Here, we show that PREs are also necessary and sufficient to mediate cAMP-induced gene expression. Prf1 interacts with cAMP-dependent protein kinase A (PKA) Adr1 as well as MAPK… CONTINUE READING
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