PKA activation and endothelial claudin-5 breakdown in the schizophrenic prefrontal cortex

@inproceedings{Nishiura2017PKAAA,
  title={PKA activation and endothelial claudin-5 breakdown in the schizophrenic prefrontal cortex},
  author={Keisuke Nishiura and Naoki Ichikawa-Tomikawa and Kotaro Sugimoto and Yasuto Kunii and Korehito Kashiwagi and Mizuko Tanaka and Yuichi Yokoyama and Mizuki Hino and Takashi Sugino and Hirooki Yabe and Hitoshi Takahashi and Akiyoshi Kakita and Tetsuya Imura and Hideki Tachibana Chiba},
  booktitle={Oncotarget},
  year={2017}
}
Schizophrenia is thought to be caused by a combination of genetic and environmental factors; however, its pathogenesis remains largely unknown. Here, we focus on the endothelial tight-junction protein claudin-5 (CLDN5), because the CLDN5 gene is mapped to the schizophrenia-associated 22q11.2 deletion region, and a single nucleotide polymorphism in the CLDN5 locus is also linked to schizophrenia. We show, by RT-qPCR and immunohistochemistry, that the expressions of CLDN5 mRNA and protein are… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 36 REFERENCES

Similar Papers

Loading similar papers…