PKA Regulates PINK1 Stability and Parkin Recruitment to Damaged Mitochondria through Phosphorylation of MIC60.

@article{Akabane2016PKARP,
  title={PKA Regulates PINK1 Stability and Parkin Recruitment to Damaged Mitochondria through Phosphorylation of MIC60.},
  author={Shiori Akabane and Midori Uno and Naoki Tani and Shunta Shimazaki and Natsumi Ebara and Hiroki Kato and Hidetaka Kosako and Toshihiko Oka},
  journal={Molecular cell},
  year={2016},
  volume={62 3},
  pages={371-384}
}
A mitochondrial kinase, PTEN-induced putative kinase 1 (PINK1), selectively recruits the ubiquitin ligase Parkin to damaged mitochondria, which modifies mitochondria by polyubiquitination, leading to mitochondrial autophagy. Here, we report that treatment with an adenylate cyclase agonist or expression of protein kinase A (PKA) impairs Parkin recruitment to damaged mitochondria and decreases PINK1 protein levels. We identified a mitochondrial membrane protein, MIC60 (also known as mitofilin… CONTINUE READING
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