PKA Phosphorylation Dissociates FKBP12.6 from the Calcium Release Channel (Ryanodine Receptor) Defective Regulation in Failing Hearts

@article{Marx2000PKAPD,
  title={PKA Phosphorylation Dissociates FKBP12.6 from the Calcium Release Channel (Ryanodine Receptor) Defective Regulation in Failing Hearts},
  author={Steven O. Marx and Steven R. Reiken and Yuji Hisamatsu and Thotalla Jayaraman and Daniel Burkhoff and Nora Rosemblit and Andrew R. Marks},
  journal={Cell},
  year={2000},
  volume={101},
  pages={365-376}
}

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Important insights are revealed regarding channel regulation of the ryanodine receptor: 1) the calcium release channel must be phosphorylated to be in the active state at conditions approximating physiological Mg concentrations (mM); and 2) there are multiple sites of phosphorylation on the calciumRelease channel with different functional consequences, which may be relevant to the regulation of E-C coupling.

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