PKA Compartmentalization via AKAP220 and AKAP12 Contributes to Endothelial Barrier Regulation

@inproceedings{Radeva2014PKACV,
  title={PKA Compartmentalization via AKAP220 and AKAP12 Contributes to Endothelial Barrier Regulation},
  author={Mariya Yosifova Radeva and Daniela Kugelmann and Volker Spindler and Jens Waschke},
  booktitle={PloS one},
  year={2014}
}
cAMP-mediated PKA signaling is the main known pathway involved in maintenance of the endothelial barrier. Tight regulation of PKA function can be achieved by discrete compartmentalization of the enzyme via physical interaction with A-kinase anchoring proteins (AKAPs). Here, we investigated the role of AKAPs 220 and 12 in endothelial barrier regulation. Analysis of human and mouse microvascular endothelial cells as well as isolated rat mesenteric microvessels was performed using TAT-Ahx-AKAPis… CONTINUE READING