PKA/AKAP/VR-1 module: A common link of Gs-mediated signaling to thermal hyperalgesia.

@article{Rathee2002PKAAKAPVR1MA,
  title={PKA/AKAP/VR-1 module: A common link of Gs-mediated signaling to thermal hyperalgesia.},
  author={Parvinder Kaur Rathee and Carsten Distler and Otilia Obreja and Winfried Neuhuber and G. K. Wang and S. Y. Wang and Carla Nau and Michaela Kress},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 11},
  pages={4740-5}
}
Inflammatory mediators not only activate "pain-"sensing neurons, the nociceptors, to trigger acute pain sensations, more important, they increase nociceptor responsiveness to produce inflammatory hyperalgesia. For example, prostaglandins activate G(s)-protein-coupled receptors and initiate cAMP- and protein kinase A (PKA)-mediated processes. We demonstrate for the first time at the cellular level that heat-activated ionic currents were potentiated after exposure to the cAMP activator forskolin… CONTINUE READING
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AKAPs: from structure to function.

Trends in cell biology • 1999
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