PK study of octreotide based on LC-MS/MS combining protein precipitation and impurity extraction technique.

@article{Wang2015PKSO,
  title={PK study of octreotide based on LC-MS/MS combining protein precipitation and impurity extraction technique.},
  author={Qian Wang and Yan Liang and T. Tirumaleswara Rao and Lin Xie and Wei Ye and Hanxu Fu and Lijun Zhou and Rong Xing and Yu-hao Shao and Jingcheng Xiao and Dian Kang and Guang-ji Wang},
  journal={Bioanalysis},
  year={2015},
  volume={7 7},
  pages={885-94}
}
AIM To establish a robust methodology for quantitative analysis of therapeutic peptide in biological samples. MATERIALS & METHODS Octreotide was chosen as a model therapeutic peptide, and oxidized-octreotide was synthesized as internal standard. Protein precipitation combining liquid-liquid extraction technique was adopted to enhance the recovery and… CONTINUE READING