PK/PD modelling of high-dose diltiazem--absorption-rate dependency of the hysteresis loop.

@article{Luckow1997PKPDMO,
  title={PK/PD modelling of high-dose diltiazem--absorption-rate dependency of the hysteresis loop.},
  author={V. Luckow and O E Della Paschoa},
  journal={International journal of clinical pharmacology and therapeutics},
  year={1997},
  volume={35 10},
  pages={418-25}
}
To investigate bioequivalence of 2 different sustained-release diltiazem formulations the preparations each containing 180 mg diltiazem-HCl were given to 20 healthy male volunteers in an open, randomized, 2-way crossover design. Blood samples were taken before drug administration and at 14 times until 30 hours post application. 12-lead ECGs were recorded at… CONTINUE READING