PJ-34 inhibits PARP-1 expression and ERK phosphorylation in glioma-conditioned brain microvascular endothelial cells.

Abstract

Inhibitors of PARP-1(Poly(ADP-ribose) polymerase-1) act by competing with NAD(+), the enzyme physiological substrate, which play a protective role in many pathological conditions characterized by PARP-1 overactivation. It has been shown that PARP-1 also promotes tumor growth and progression through its DNA repair activity. Since angiogenesis is an essential… (More)
DOI: 10.1016/j.ejphar.2015.04.026

Topics

1 Figure or Table

Cite this paper

@article{Motta2015PJ34IP, title={PJ-34 inhibits PARP-1 expression and ERK phosphorylation in glioma-conditioned brain microvascular endothelial cells.}, author={Carla Motta and Floriana D'Angeli and M. Scalia and Cristina Satriano and Davide Barbagallo and Irina Vladimirovna Naletova and Carmelina Daniela Anfuso and Gabriella Lupo and Vittoria Spina-Purrello}, journal={European journal of pharmacology}, year={2015}, volume={761}, pages={55-64} }