PIWI-interacting small RNAs: the vanguard of genome defence

@article{Siomi2011PIWIinteractingSR,
  title={PIWI-interacting small RNAs: the vanguard of genome defence},
  author={Mikiko C. Siomi and Kaoru Sato and Dubravka Pezic and Alexei A. Aravin},
  journal={Nature Reviews Molecular Cell Biology},
  year={2011},
  volume={12},
  pages={246-258}
}
PIWI-interacting RNAs (piRNAs) are a distinct class of small non-coding RNAs that form the piRNA-induced silencing complex (piRISC) in the germ line of many animal species. The piRISC protects the integrity of the genome from invasion by 'genomic parasites' — transposable elements — by silencing them. Owing to their limited expression in gonads and their sequence diversity, piRNAs have been the most mysterious class of small non-coding RNAs regulating RNA silencing. Now, much progress is being… 
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