PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression.

Abstract

BACKGROUND Intergenic variations on chromosome 4q25, close to the PITX2 transcription factor gene, are associated with atrial fibrillation (AF). We therefore tested whether adult hearts express PITX2 and whether variation in expression affects cardiac function. METHODS AND RESULTS mRNA for PITX2 isoform c was expressed in left atria of human and mouse… (More)
DOI: 10.1161/CIRCGENETICS.110.958058

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@article{Kirchhof2011PITX2cIE, title={PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression.}, author={Paulus Kirchhof and Peter C. Kahr and Sven Kaese and Ilaria Piccini and Ismail Vokshi and H Scheld and Heinrich Rotering and Lisa Fortmueller and Sandra Laakmann and Sander Verheule and Ulrich Schotten and Larissa Fabritz and Nigel Brown}, journal={Circulation. Cardiovascular genetics}, year={2011}, volume={4 2}, pages={123-33} }