PITX2C loss-of-function mutations responsible for idiopathic atrial fibrillation

OBJECTIVE This study aimed to identify novel PITX2c mutations responsible for idiopathic atrial fibrillation. METHODS A cohort of 210 unrelated patients with idiopathic atrial fibrillation and 200 unrelated, ethnically matched healthy individuals used as controls were recruited. The whole coding exons and splice junctions of the PITX2c gene, which encodes… CONTINUE READING