PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5.

@article{Ganga2003PITX2IR,
  title={PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5.},
  author={Mrudula Ganga and Herbert M. Espinoza and Carol J. Cox and Lisa Morton and Tord A.H. Hjalt and Youngsook Lee and Brad A Amendt},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 25},
  pages={22437-45}
}
PITX2 and Nkx2.5 are two of the earliest known transcriptional markers of vertebrate heart development. Pitx2-/- mice present with severe cardiac malformations and embryonic lethality, demonstrating a role for PITX2 in heart development. However, little is known about the downstream targets of PITX2 in cardiogenesis. We report here that the atrial natriuretic factor (ANF) promoter is a target of PITX2. PITX2A, PITX2B, and PITX2C isoforms differentially activate the ANF promoter. However, only… CONTINUE READING