PITX2, beta-catenin and LEF-1 interact to synergistically regulate the LEF-1 promoter.

@article{Vadlamudi2005PITX2BA,
  title={PITX2, beta-catenin and LEF-1 interact to synergistically regulate the LEF-1 promoter.},
  author={Usha Vadlamudi and Herbert M. Espinoza and Mrudula Ganga and Donna M. Martin and Xiaoming Liu and John F. Engelhardt and Brad A Amendt},
  journal={Journal of cell science},
  year={2005},
  volume={118 Pt 6},
  pages={1129-37}
}
PITX2, beta-catenin and lymphoid enhancer factor (LEF-1) are required for the inductive formation of several epithelial-derived organs, including teeth. Lef-1 is expressed in the dental epithelium after Pitx2, and both factors have overlapping expression patterns in the tooth bud and cap stages. Our analysis of Pitx2-/- mutant mice showed reduced Lef-1 expression in facial tissues by RT-PCR and quantitative RT-PCR. Consistent with these results we show that the human 2.5 kb LEF-1 promoter is… CONTINUE READING
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