PITALRE, the catalytic subunit of TAK, is required for human immunodeficiency virus Tat transactivation in vivo.

@article{Gold1998PITALRETC,
  title={PITALRE, the catalytic subunit of TAK, is required for human immunodeficiency virus Tat transactivation in vivo.},
  author={M O Gold and Xinzhen Yang and Christine H Herrmann and Andrew P. Rice},
  journal={Journal of virology},
  year={1998},
  volume={72 5},
  pages={4448-53}
}
The human cdc2-related kinase PITALRE is the catalytic component of TAK, the Tat-associated kinase. Previously, we have proposed that TAK is a cellular factor that mediates Tat transactivation function. Here we demonstrate that transient overexpression of PITALRE specifically squelches Tat-1 activation of both a transfected and an integrated human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR), suggesting that PITALRE mediates Tat function as a multiprotein complex. A… CONTINUE READING

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