PIP4kγ is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation

  title={PIP4kγ is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation},
  author={A. Mackey and Deborah A. Sarkes and I. Bettencourt and J. Asara and L. Rameh},
  journal={Science Signaling},
  pages={ra104 - ra104}
  • A. Mackey, Deborah A. Sarkes, +2 authors L. Rameh
  • Published 2014
  • Biology, Medicine
  • Science Signaling
  • A feedback loop involving PIP4kγ and mTORC1 maintains basal mTORC1 activity under nutrient-deprived conditions. Maintaining a Basal Level of Activity Nutrients such as glucose and amino acids activate mammalian target of rapamycin complex 1 (mTORC1), a complex consisting of the kinase mTOR, which couples metabolic signals to pathways that trigger cellular proliferation and growth. When nutrients are limiting, mTORC1 activity is normally suppressed. Mackey et al. found that under nutrient… CONTINUE READING
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