PIP3 waves and PTEN dynamics in the emergence of cell polarity.

@article{Gerisch2012PIP3WA,
  title={PIP3 waves and PTEN dynamics in the emergence of cell polarity.},
  author={G{\"u}nther Gerisch and Britta Schroth-Diez and Annette Mueller-Taubenberger and Mary Ecke},
  journal={Biophysical journal},
  year={2012},
  volume={103 6},
  pages={
          1170-8
        }
}
In a motile eukaryotic cell, front protrusion and tail retraction are superimposed on each other. To single out mechanisms that result in front to tail or in tail to front transition, we separated the two processes in time using cells that oscillate between a full front and a full tail state. State transitions were visualized by total internal reflection fluorescence microscopy using as a front marker PIP3 (phosphatidylinositol [3,4,5] tris-phosphate), and as a tail marker the tumor-suppressor… CONTINUE READING
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