PIP2 and PIP3 interact with N-terminus region of TRPM4 channel.

  title={PIP2 and PIP3 interact with N-terminus region of TRPM4 channel.},
  author={Krist{\'y}na Bou{\vs}ov{\'a} and Michaela Jirku and Ladislav Bumba and Lucie Bedn{\'a}rov{\'a} and Miroslav {\vS}ulc and Miloslav Franěk and Ladislav Vyklick{\'y} and Jiř{\'i} Vondr{\'a}{\vs}ek and Jan Teisinger},
  journal={Biophysical chemistry},
The transient receptor potential melastatin 4 (TRPM4) is a calcium-activated non-selective ion channel broadly expressed in a variety of tissues. Receptor has been identified as a crucial modulator of numerous calcium dependent mechanisms in the cell such as immune response, cardiac conduction, neurotransmission and insulin secretion. It is known that phosphoinositide lipids (PIPs) play a unique role in the regulation of TRP channel function. However the molecular mechanism of this process is… CONTINUE READING
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