PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse.

@article{Wenk2001PIPKI,
  title={PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse.},
  author={Markus R. Wenk and Luca Pellegrini and Vadim A. Klenchin and Gilbert Di Paolo and Susannah Chang and Laurie Daniell and Manabu Arioka and Thomas F.J Martin and Pietro De Camilli},
  journal={Neuron},
  year={2001},
  volume={32 1},
  pages={
          79-88
        }
}
Disruption of the presynaptically enriched polyphosphoinositide phosphatase synaptojanin 1 leads to an increase of clathrin-coated intermediates and of polymerized actin at endocytic zones of nerve terminals. These changes correlate with elevated levels of PI(4,5)P(2) in neurons. We report that phosphatidylinositol phosphate kinase type Igamma (PIPKIgamma), a major brain PI(4)P 5-kinase, is concentrated at synapses. Synaptojanin 1 and PIPKIgamma antagonize each other in the recruitment of… CONTINUE READING

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