PIP 3 inhibition of RGS protein and its reversal by Ca 2 calmodulin mediate voltage-dependent control of the G protein cycle in a cardiac

@inproceedings{Ishii2002PIP3I,
  title={PIP 3 inhibition of RGS protein and its reversal by Ca 2 calmodulin mediate voltage-dependent control of the G protein cycle in a cardiac},
  author={Masaru Ishii and Atsushi Inanobe and Yoshihisa Kurachi},
  year={2002}
}
Regulators of G protein signaling (RGS) accelerate intrinsic GTP hydrolysis on subunits of trimeric G proteins and play crucial roles in the physiological regulation of G protein-mediated cell signaling. The control mechanisms of the action of RGS proteins per se are poorly clarified, however. We recently showed a physiological mode of action of a RGS protein in cardiac myocytes. The voltagedependent formation of Ca2 calmodulin facilitated the GTPase activity of RGS by an unidentified mechanism… CONTINUE READING

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