PIP(2) regulates the ionic current of P2X receptors and P2X(7) receptor-mediated cell death.

@article{Zhao2007PIP2RT,
  title={PIP(2) regulates the ionic current of P2X receptors and P2X(7) receptor-mediated cell death.},
  author={Qi Zhao and Min Yang and Adrian T. Ting and Diomedes E. Logothetis},
  journal={Channels},
  year={2007},
  volume={1 1},
  pages={46-55}
}
P2X(7) receptors are non-selective cation channels gated by extracellular ATP. Prolonged stimulation of the P2X(7) receptor leads to an increase in cell permeability, cytokine release and apoptosis/necrosis. Application of PIP(2) to inside-out patches strongly activated all homomeric members of the P2X receptor family, including P2X(7) channels. Blockade of PIP(2) re-synthesis or induction of PIP(2) hydrolysis diminished ATP-gated P2X(7) currents. Several positively charged residues in the… CONTINUE READING

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