PINK1 displays tissue-specific subcellular location and regulates apoptosis and cell growth in breast cancer cells.

@article{Berthier2011PINK1DT,
  title={PINK1 displays tissue-specific subcellular location and regulates apoptosis and cell growth in breast cancer cells.},
  author={Arnaud Berthier and Samuel Navarro and Judit Jim{\'e}nez-S{\'a}inz and Isabel Rogl{\'a} and Francisca Ripoll and Javier Cervera and Rafael Pulido},
  journal={Human pathology},
  year={2011},
  volume={42 1},
  pages={75-87}
}
The PINK1 gene is mutated in the germ line of patients with hereditary early-onset Parkinson disease, and PINK1 prosurvival function at neuronal mitochondria has been related with the etiology of this disease. However, the expression and function of PINK1 protein in nonneuronal tissues has not been determined yet. Here, we have analyzed PINK1 protein expression and subcellular distribution in normal and neoplastic human tissues and investigated the function of PINK1 in breast carcinoma cells… CONTINUE READING

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