PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival.

@article{Lee2017PINK1PP,
  title={PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival.},
  author={Yunjong Dae Lee and Daniel A Stevens and Sung-Ung Kang and Haisong Jiang and Yun-il Lee and Han Seok Ko and Leslie Scarffe and George K E Umanah and Hojin Kang and Sangwoo Ham and T. Kam and Kathleen G Allen and Saurav Brahmachari and Jungwoo Wren Kim and Stewart Neifert and Seung Yun and Fabienne C. Fiesel and Wolfdieter Springer and Valina L Dawson and Joo-ho Shin and Ted M Dawson},
  journal={Cell reports},
  year={2017},
  volume={18 4},
  pages={918-932}
}
Mutations in PTEN-induced putative kinase 1 (PINK1) and parkin cause autosomal-recessive Parkinson's disease through a common pathway involving mitochondrial quality control. Parkin inactivation leads to accumulation of the parkin interacting substrate (PARIS, ZNF746) that plays an important role in dopamine cell loss through repression of proliferator-activated receptor gamma coactivator-1-alpha (PGC-1α) promoter activity. Here, we show that PARIS links PINK1 and parkin in a common pathway… CONTINUE READING
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