PINK1 Is Dispensable for Mitochondrial Recruitment of Parkin and Activation of Mitophagy in Cardiac Myocytes

@inproceedings{Kubli2015PINK1ID,
  title={PINK1 Is Dispensable for Mitochondrial Recruitment of Parkin and Activation of Mitophagy in Cardiac Myocytes},
  author={Dieter A. Kubli and Melissa Q. Cortez and Alexandra G. Moyzis and Rita H. Najor and Youngil Lee and {\AA} B Gustafsson and Junichi Sadoshima},
  booktitle={PloS one},
  year={2015}
}
Myocyte function and survival relies on the maintenance of a healthy population of mitochondria. The PINK1/Parkin pathway plays an important role in clearing defective mitochondria via autophagy in cells. However, how the PINK1/Parkin pathway regulates mitochondrial quality control and whether it coordinates with other mitophagy pathways are still unclear. Therefore, the objective of this study was to investigate the effect of PINK1-deficiency on mitochondrial quality control in myocytes. Using… CONTINUE READING