PINK1/Parkin-mediated mitophagy in mammalian cells.

  title={PINK1/Parkin-mediated mitophagy in mammalian cells.},
  author={Akinori Eiyama and Koji Okamoto},
  journal={Current opinion in cell biology},
Mitochondria-specific autophagy (mitophagy) is a fundamental process critical for maintaining mitochondrial fitness in a myriad of cell types. Particularly, mitophagy contributes to mitochondrial quality control by selectively eliminating dysfunctional mitochondria. In mammalian cells, the Ser/Thr kinase PINK1 and the E3 ubiquitin ligase Parkin act cooperatively in sensing mitochondrial functional state and marking damaged mitochondria for disposal via the autophagy pathway. Notably, ubiquitin… CONTINUE READING
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