PINK1/Parkin-mediated mitophagy in mammalian cells.

@article{Eiyama2015PINK1ParkinmediatedMI,
  title={PINK1/Parkin-mediated mitophagy in mammalian cells.},
  author={Akinori Eiyama and Koji Okamoto},
  journal={Current opinion in cell biology},
  year={2015},
  volume={33},
  pages={95-101}
}
Mitochondria-specific autophagy (mitophagy) is a fundamental process critical for maintaining mitochondrial fitness in a myriad of cell types. Particularly, mitophagy contributes to mitochondrial quality control by selectively eliminating dysfunctional mitochondria. In mammalian cells, the Ser/Thr kinase PINK1 and the E3 ubiquitin ligase Parkin act cooperatively in sensing mitochondrial functional state and marking damaged mitochondria for disposal via the autophagy pathway. Notably, ubiquitin… CONTINUE READING
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PINK1 Catalytic Activity is Regulated by Phosphorylation on Serines 228 and 402

  • L Aerts, K Craessaerts, B De Strooper, VA Morais
  • J Biol Chem
  • 2015
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