PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha.

@article{Eke2010PINCH1RA,
  title={PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha.},
  author={Iris Eke and Ulrike Koch and Stephanie Hehlgans and Veit Sandfort and Fabio Stanchi and Daniel Zips and Michael Baumann and Anna Shevchenko and Christian Pilarsky and Michael Haase and Gustavo Bruno Baretton and V{\'e}ronique Calleja and Banafsh{\'e} Larijani and Reinhard F{\"a}ssler and Nils Cordes},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 7},
  pages={2516-27}
}
Tumor cell resistance to ionizing radiation and chemotherapy is a major obstacle in cancer therapy. One factor contributing to this is integrin-mediated adhesion to ECM. The adapter protein particularly interesting new cysteine-histidine-rich 1 (PINCH1) is recruited to integrin adhesion sites and promotes cell survival, but the mechanisms underlying this effect are not well understood. Here we have shown that PINCH1 is expressed at elevated levels in human tumors of diverse origins relative to… CONTINUE READING