PINCH: More than just an adaptor protein in cellular response.

  title={PINCH: More than just an adaptor protein in cellular response.},
  author={Jane Kovalevich and Brittany A Tracy and Dianne Langford},
  journal={Journal of cellular physiology},
  volume={226 4},
Particularly interesting new cysteine-histidine-rich protein (PINCH) is a LIM-domain-only adaptor protein involved in protein recruitment, subsequent assembly of multi-protein complexes, and subcellular localization of these complexes. PINCH is developmentally regulated and its expression is critical for proper cytoskeletal organization and extracellular matrix adhesion. Although PINCH has no catalytic abilities, the PIP (PINCH-ILK-parvin) complex serves as a link between integrins and… CONTINUE READING


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